Chronic intermittent hypoxia enhances cat chemosensory and ventilatory responses to hypoxia
نویسندگان
چکیده
منابع مشابه
Chronic intermittent hypoxia alters ventilatory and metabolic responses to acute hypoxia in rats.
We determined the effects of chronic exposure to intermittent hypoxia (CIH) on chemoreflex control of ventilation in conscious animals. Adult male Sprague-Dawley rats were exposed to CIH [nadir oxygen saturation (SpO2), 75%; 15 events/h; 10 h/day] or normoxia (NORM) for 21 days. We assessed the following responses to acute, graded hypoxia before and after exposures: ventilation (V̇e, via baromet...
متن کاملChronic intermittent hypoxia reduces ventilatory long-term facilitation and enhances apnea frequency in newborn rats.
Ventilatory long-term facilitation (LTF; defined as gradual increase of minute ventilation following repeated hypoxic exposures) is well described in adult mammals and is hypothesized to be a protective mechanism against apnea. In newborns, LTF is absent during the first postnatal days, but its precise developmental pattern is unknown. Accordingly, this study describes this pattern of postnatal...
متن کاملChronic intermittent hypoxia enhances ventilatory long-term facilitation in awake rats.
This study examined the effect of chronic intermittent hypoxia (CIH: 5 min 11-12% O2/5 min air, 12 h/night, 7 nights) on ventilatory long-term facilitation (LTF) and determined the persistence period of this CIH effect in awake rats. LTF, elicited by 5 or 10 episodes of 5 min 12% O2, was measured four times in the same Sprague-Dawley rats by plethysmography, before and 8 h, 3 days, and 7 days a...
متن کاملChronic intermittent hypoxia increases sympathetic responsiveness to hypoxia and hypercapnia.
We sought to determine whether chronic exposure to intermittent hypoxia (CIH) increases sympathetic responsiveness to subsequent chemoreflex stimulation. Sprague-Dawley rats were exposed to 30 days of CIH: exposure chamber %O2 [fractional concentration of chamber O2 (FcO2)] nadir 6.5-7% with return to 21% each minute for 8 h/day during the diurnal sleep period (Exp group). Sham controls (SC gro...
متن کاملFructose feeding and intermittent hypoxia affect ventilatory responsiveness to hypoxia and hypercapnia in rats.
We hypothesized that, in male rats, 10% fructose in drinking water would depress ventilatory responsiveness to acute hypoxia (10% O2 in N2) and hypercapnia (5% CO2 in O2) that would be depressed further by exposure to intermittent hypoxia. Minute ventilation (Ve) in air and in response to acute hypoxia and hypercapnia was evaluated in 10 rats before fructose feeding (FF), during 6 wk of FF, and...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2004
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2004.072033